Examinando por Autor "Jimenez Morales, Laura Catalina"
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Ítem Comportamiento de los marcadores bioquímicos y ecográficos implementados en el tamizaje de cromosomopatías durante el primer trimestre de embarazo, en una muestra de mujeres en Bogotá entre el 2014-2018(Universidad El Bosque, 2020) Gutiérrez Ardila, María Alejandra; Hernández Alomia, María Fernanda; Hernández Villarraga, Andrés Felipe; Jimenez Morales, Laura Catalina; Romero Infante, Ximena Carolina; Uriel Calvo,María Montserrat; Malagón Rojas, Jeadran Nevardo; Romero Infante, Ximena Carolina [0000-0002-7040-2705]; Uriel Calvo,María Montserrat [0000-0001-5987-8633]Objective: To describe the behavior of the ultrasound and serological markers used in the screening of chromosomopathies during the first trimester of pregnancy, in a sample of pregnant women in Bogotá. Methods: An observational descriptive study was conducted within a prospective multicentric study with 566 pregnant women studied during 11 to 14 weeks of pregnancy between 2014-2018. Six of them presented twin pregnancy, therefore 572 fetuses were studied. The behavior of the ultrasound and serological variables were analyzed, comparing the results obtained in the sample with those described in the literature. Results: Serological and ultrasound markers used in the screening, showed a similar behavior with respect to the parameters of normality. On the other hand, the behavior of the ductus venosus had a significant statistical relation with the gestational age. The nuchal translucency showed a statistically significant association with the maternal body mass index (BMI) and gestational age. The free fraction of beta subunit of human chorionic gonadotropin (free β-hCG) and pregnancy-associated plasma protein A (PAPP-A) had a significant relationship with maternal BMI. As well, the placenta growth factor had an independent relation with the other evaluated maternal variables. Conclusions: The serological and ultrasound markers used in the chromosomopathies screening during the first trimester of pregnancy in the sample of Colombian population studied, showed a significant relationship between maternal characteristics versus the markers implemented (free β-HCG and PAPP-A) and those had a similar behavior with the international literature. With the exception of the PlGF, which had an independent behavior, a correlation not described in the literature reviewed.