Acute toxicity evaluation of the ethanolic extract from leaves and flowers of chromolaena perglabra (b. l. robinson) king & h. rob.
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Fecha
2018
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PharmacologyOnLine, 1827-8620, Vol 3, 2018, pag 136-144
Publicado por
Società Italo-Latinoamericana di Etnomedicina
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Abstract
At present, there is a great variety of plant species widely distributed in different geographical
regions worldwide, with phytopharmacological potential; however, its indiscriminate use has limited
access to vegetal resources by the population in general and the scientific community. Additionally, the
lack of toxicological studies that provide knowledge on the safety of their use makes the problem more
critical. According to traditional knowledge, the species that belong to the genus Chromolaena, have a
high pharmacological potential, but currently, there are no studies that validate traditional use and
safety. Therefore, the purpose of this investigation was to evaluate the acute toxicity of the leaf and
flower extract of Chromolaena perglabra (C. perglabra) in mice. To develop this aim, 25 female ICR-CD1
mice were divided into two groups with three and two subgroups respectively, to which they were
administered intraperitoneally 125, 250, 500, 1000 and 2000 mg / kg of the ethanolic extract of leaves
and flowers of C. perglabra; another 5 mice were administered the vehicle (control group); 72 hours
after inoculation, they were sacrificed for histopathological study (macroscopic and microscopic). An
increase in size was observed with mild lymphoid hyperplasia in the spleen and toxic hepatitis in all the
animals, the rest of the organs analyzed were in normal conditions
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Keywords
Acute toxicity, Chromolaena perglabra, Asteraceae, Medicinal plants
Temáticas
Chromolaena
Plantas medicinales
Magnoliopsida
Plantas medicinales
Magnoliopsida