A review of combination antimicrobial therapy for enterococcus faecalis bloodstream infections and infective endocarditis

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dc.contributor.authorBeganovic, Maya
dc.contributor.authorLuther, Megan K
dc.contributor.authorRice, Louis B
dc.contributor.authorArias, Cesar A
dc.contributor.authorRybak, Michael J
dc.contributor.authorLaPlante, Kerry L
dc.date.accessioned2020-05-15T16:26:22Z
dc.date.available2020-05-15T16:26:22Z
dc.date.issued2018
dc.description.abstractenglishEnterococci, one of the most common causes of hospital-associated infections, are responsible for substantial morbidity and mortality. Enterococcus faecalis, the more common and virulent species, causes serious high-inoculum infections, namely infective endocarditis, that are associated with cardiac surgery and mortality rates that remained unchanged for the last 30 years. The best cures for these infections are observed with combination antibiotic therapy; however, optimal treatment has not been fully elucidated. It is the purpose of this review to highlight treatment options and their limitations, and provide direction for future investigative efforts to aid in the treatment of these severe infections. While ampicillin plus ceftriaxone has emerged as a preferred treatment option, mortality rates continue to be high, and from a safety standpoint, ceftriaxone, unlike other cephalosporins, promotes colonization with vancomycin resistant-enterococci due to high biliary concentrations. More research is needed to improve patient outcomes from this high-mortality disease.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/cid/ciy064
dc.identifier.issn1537-6591
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2827
dc.language.isoeng
dc.publisherOxford University Pressspa
dc.publisher.journalClinical Infectious Diseasesspa
dc.relation.ispartofseriesClinical Infectious Diseases, 1537-6591, Vol 67, Num 2, 2018, pag 303-309spa
dc.relation.urihttps://academic.oup.com/cid/article/67/2/303/4829420
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsEnterococcusspa
dc.subject.decsEndocarditisspa
dc.subject.keywordsEnterococcus faecalisspa
dc.subject.keywordsInfective endocarditisspa
dc.subject.keywordsAntimicrobialsspa
dc.titleA review of combination antimicrobial therapy for enterococcus faecalis bloodstream infections and infective endocarditisspa
dc.title.translatedA review of combination antimicrobial therapy for enterococcus faecalis bloodstream infections and infective endocarditisspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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