Evaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trial

Vista sencilla de ítem
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.authorZaror, C.
dc.contributor.authorDíaz‐Báez, D.
dc.contributor.authorCastillo, DM
dc.contributor.authorDe Ávila, J.
dc.contributor.authorTrujillo, TG.
dc.contributor.authorCalderón‐Mendoza, J.
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.date.accessioned2020-05-18T07:51:20Z
dc.date.available2020-05-18T07:51:20Z
dc.date.issued2018
dc.description.abstractenglishBackground Hypochlorous acid (HOCl) is a non‐antibiotic antimicrobial substance with significant effects on pathogenic oral micro‐organisms. The effects of HOCl as an antiplaque agent have not been studied. Objective The aim of this study was to evaluate the substantivity of HOCl mouthwashes compared with chlorhexidine (CHX) rinses and a placebo. Materials and Methods A double‐blind randomized controlled trial with 75 participants was conducted. Participants were divided into five groups using block randomization: 0.025% HOCl, 0.05% HOCl, 0.12% CHX, 0.2% CHX, and sterile water as a placebo. Participants were instructed to use each rinse solution for 30 seconds after dental prophylaxis. Samples of saliva were taken at baseline and after 30 seconds, 1, 3, 5 and 7 hours to assess substantivity, and bacterial viability was established by the fluorescence method. Visible plaque in all participants was assessed with the Turesky index at baseline and at 7 hours, and adverse events were also assessed. Results HOCl led to a 33% reduction in bacterial counts in the saliva after 30 seconds compared with a 58% reduction by CHX. HOCl has no substantivity, and bacterial counts returned to baseline after 1 hour. Placebo treatment led to the highest plaque count after 7 hours compared with the CHX and HOCl groups, although the differences were not significant. HOCl rinsing induced the highest percentages of unpleasant taste and dryness sensations. Conclusions HOCl rinses have an initial effect on bacterial viability in saliva but have no substantivity. Other mechanisms may explain its antiplaque effect.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/idh.12342
dc.identifier.issn1601-5037
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2914
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalInternational journal of dental hygienespa
dc.relation.ispartofseriesInternational journal of dental hygiene, 1601-5037, Vol 16, Num 4, 2018, pag 527-534spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/idh.12342
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsPlaca dentalspa
dc.subject.decsGuanidinasspa
dc.subject.decsÁcido hipoclorosospa
dc.subject.keywordsAntiplaque agentsspa
dc.subject.keywordsChlorhexidinespa
dc.subject.keywordsHypochlorous acidspa
dc.subject.keywordsSubstantivityspa
dc.titleEvaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trialspa
dc.title.translatedEvaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trialspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

Archivos

Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos