HLA-DRB1*14 is a protective allele for multiple sclerosis in an admixed Colombian population

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dc.contributor.authorToro, Jaime
dc.contributor.authorCuellar Giraldo, David
dc.contributor.authorDíaz Cruz, Camilo
dc.contributor.authorBurbano, Lisseth Estefania
dc.contributor.authorReyes, Saúl
dc.contributor.authorCárdenas Robledo, Simón
dc.contributor.authorNarváez, Diana M.
dc.contributor.authorCárdenas, Wilmer
dc.contributor.authorPorras-Ramírez, Alexandra
dc.contributor.authorLattig, María Claudia
dc.contributor.authorGroot, Helena
dc.contributor.authorGuío, Claudia-Marcela
dc.contributor.authorCortés Muñoz, Fabián
dc.contributor.orcidPorras-Ramírez, Alexandra [0000-0002-0800-1388]
dc.contributor.orcidToro, Jaime [0000-0001-7129-0058]
dc.date.accessioned2019-09-06T20:32:55Z
dc.date.available2019-09-06T20:32:55Z
dc.date.issued2016
dc.description.abstractenglishObjective: The aim of this study was to determine ancestry informative markers, mitochondrial DNA haplogroups, and the association between HLA-DRB1 alleles and multiple sclerosis (MS) in a group of patients from Bogotá, Colombia. Methods: In this case-control study, genomic DNA was isolated and purified from blood samples. HLA-DRB1 allele genotyping was done using PCR. Mitochondrial hypervariable region 1 was amplified and haplogroups were determined using HaploGrep software. Genomic ancestry was estimated by genotyping a panel of ancestry informative markers. To test the association of HLA polymorphisms and MS, we ran separate multivariate logistic regression models. Bonferroni correction was used to account for multiple regression tests. Results: A total of 100 patients with MS (mean age 40.4 ± 12 years; 70% females) and 200 healthy controls (mean age 37.6 ± 11 years; 83.5% females) were included in the analysis. Ancestry proportions and haplogroup frequencies did not differ between patients and controls. HLA-DRB1*15 was present in 31% of cases and 13.5% of controls, whereas HLA-DRB1*14 was present in 5% of cases and 15.5% of controls. In the multivariate model, HLA-DRB1*15 was significantly associated with MS (odds ratio [OR] = 3.05, p < 0.001), whereas HLA-DRB1*14 was confirmed as a protective factor in our population (OR = 0.16, p = 0.001). Conclusions: This study provides evidence indicating that HLA-DRB1*15 allele confers susceptibility to MS and HLA-DRB1*14 allele exerts resistance to MS in a highly admixed population. This latter finding could partially explain the low prevalence of MS in Bogotá, Colombia.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1212/NXI.0000000000000192
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2332-7812
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1663
dc.language.isoeng
dc.publisherLippincott Williams and Wilkinsspa
dc.publisher.journalNeurology: Neuroimmunology and NeuroInflammationspa
dc.relation.ispartofseriesNeurology: Neuroimmunology and NeuroInflammation, 2332-7812 Vol. 3, Nro, 1, 2016spa
dc.relation.urihttps://nn.neurology.org/content/3/1/e192
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf325
dc.rights.creativecommons2016
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.decsHistocompatibilidadspa
dc.subject.decsEsclerosis múltiplespa
dc.subject.decsADN Mitocondrialspa
dc.subject.decsAntígenos HLA-DRspa
dc.titleHLA-DRB1*14 is a protective allele for multiple sclerosis in an admixed Colombian populationspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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