Improved Immune Responses Against Zika Virus After Sequential Dengue and Zika Virus Infection in Humans

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dc.contributor.authorDelgado Tiria, Felix Giovanni
dc.contributor.authorTorres, Karina I.
dc.contributor.authorCastellanos, Jaime
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.authorSimon Lorière, Etienne
dc.contributor.authorSakuntabhai, Anavaj
dc.contributor.authorRoth, Claude
dc.contributor.orcidCastellanos, Jaime [0000-0003-1596-8383]
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidDelgado Tiria, Felix Giovanni [0000-0001-6685-7507]
dc.contributor.orcidDelgado Tiria, Felix Giovanni [0000-0001-6685-7507]
dc.date.accessioned2019-09-19T19:03:21Z
dc.date.available2019-09-19T19:03:21Z
dc.date.issued2018
dc.description.abstractenglishThe high levels of dengue-virus (DENV) seroprevalence in areas where the Zika virus (ZIKV) is circulating and the cross-reactivity between these two viruses have raised concerns on the risk of increased ZIKV disease severity for patients with a history of previous DENV infections. To determine the role of DENV preimmunity in ZIKV infection, we analyzed the T- and B-cell responses against ZIKV in donors with or without previous DENV infection. Using peripheral blood mononuclear cells (PBMCs) from donors living in an endemic area in Colombia, we have identified, by interferon (IFN)- enzyme-linked immunospot (ELISPOT) assay, most of the immunodominant ZIKV T-cell epitopes in the nonstructural (NS) proteins NS1, NS3, and NS5. Analyses of the T- and B-cell responses in the same donors revealed a stronger T-cell response against peptides conserved between DENV and ZIKV, with a higher level of ZIKV-neutralizing antibodies in DENV-immune donors in comparison with DENV-naïve donors. Strikingly, the potential for antibody-mediated enhancement of ZIKV infection was reduced in donors with sequential DENV and ZIKV infection in comparison with donors with DENV infection only. Altogether, these data suggest that individuals with DENV immunity present improved immune responses against ZIKV.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/v10090480
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1999-4915
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1741
dc.language.isoeng
dc.publisherMDPIspa
dc.publisher.journalVirusesspa
dc.relation.ispartofseriesViruses, 1999-4915, Vol. 10,Nro. 9 2018, p. 1-20spa
dc.relation.urihttps://www.mdpi.com/1999-4915/10/9/480
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf117
dc.rights.creativecommons2018
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsVirus del denguespa
dc.subject.decsEpítoposspa
dc.subject.decsAntígenosspa
dc.subject.decsVirus zikaspa
dc.subject.keywordsDengue virusspa
dc.subject.keywordsZika virusspa
dc.subject.keywordsT-cell epitopesspa
dc.subject.keywordsCross-reactive T cellsspa
dc.titleImproved Immune Responses Against Zika Virus After Sequential Dengue and Zika Virus Infection in Humansspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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