The natural history of solitary post-nephrectomy kidney in a pediatric population

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dc.contributor.authorCatalina, Sánchez Basto
dc.contributor.authorPuerto Niño, Angie
dc.contributor.authorFernández, Nicolas
dc.contributor.authorCastillo, Mariangel
dc.contributor.authorESPITALETA, ZILAC
dc.contributor.authorQuintero Gómez, Ana María
dc.contributor.authorPérez Niño, Jaime
dc.date.accessioned2020-05-07T00:14:49Z
dc.date.available2020-05-07T00:14:49Z
dc.date.issued2019
dc.description.abstractenglishIntroduction: Children with a solitary post-nephrectomy kidney (SNK) are at potential risk of developing kidney disease later in life. In response to the global decline in the number of nephrons, adaptive mechanisms lead to renal injury. The aim of this study was to determine the prevalence and time of onset of high blood pressure (HBP), pro-teinuria, glomerular fi ltration rate (GFR) disruption and renal tubular acidosis (RTA) in children with SNK.Materials and methods: After obtaining the approval from our institution’s ethics com-mittee, we reviewed the medical records of patients under 18 years of age who un-derwent unilateral nephrectomy between January 2005 and December 2015 in three university hospitals.Results: We identifi ed 43 patients, 35 (81.4%) cases of unilateral nephrectomy (UNP) were due to a non-oncologic pathology and Wilm’s tumor was identifi ed in 8 (18.6%) cases. In patients with non-oncologic disease, 9.3% developed de novo hypertension, with an average time of onset of 7.1 years, 25% developed proteinuria de novo, with an average time of onset of 2.2 years. For GFR, 21.8% presented deterioration of the GFR in an average time of 3.4 years. Ten (43.5%) patients developed some type of de novo renal injury after UNP. Patients with oncologic disease developed the conditions slowly and none of them developed proteinuria.Conclusions: Taking into account the high rate of long term postoperative renal injury, it can be considered that nephrectomy does not prevent this disease. The follow-up of children with SNK requires a multidisciplinary approach and long-term surveillance to detect renal injury.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1590/s1677-5538.ibju.2018.0291
dc.identifier.issn1227-1237
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2485
dc.language.isoeng
dc.publisherBrazilian Society of Urologyspa
dc.publisher.journalInternational braz j urol : official journal of the Brazilian Society of Urologyspa
dc.publisher.journalInternational braz j urol : official journal of the Brazilian Society of Urologyspa
dc.relation.ispartofseriesInternational braz j urol : official journal of the Brazilian Society of Urology, 1677-6119, Vol. 45, Nro. 6, 2019, p. 1227-1237spa
dc.relation.urihttps://www.scielo.br/scielo.php?pid=S1677-55382019000601227&script=sci_abstract
dc.rightsAttribution 4.0 International*
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsPresión arterialspa
dc.subject.decsProteinuriaspa
dc.subject.decsAcidosis tubular renalspa
dc.subject.keywordsSolitary Kidneyspa
dc.subject.keywordsRenal insuffiiciencyspa
dc.subject.keywordsNephrectomyspa
dc.titleThe natural history of solitary post-nephrectomy kidney in a pediatric populationspa
dc.title.translatedThe natural history of solitary post-nephrectomy kidney in a pediatric populationspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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