Mechanisms of antimicrobial resistance among hospital-associated pathogens

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dc.contributor.authorKhan, Ayesha
dc.contributor.authorMiller, William R.
dc.contributor.authorArias, Cesar A.
dc.date.accessioned2020-05-18T09:44:41Z
dc.date.available2020-05-18T09:44:41Z
dc.date.issued2018
dc.description.abstractenglishIntroduction: The introduction of antibiotics revolutionized medicine in the 20th-century permitting the treatment of once incurable infections. Widespread use of antibiotics, however, has led to the development of resistant organisms, particularly in the healthcare setting. Today, the clinician is often faced with pathogens carrying a cadre of resistance determinants that severely limit therapeutic options. The genetic plasticity of microbes allows them to adapt to stressors via genetic mutations, acquisition or sharing of genetic material and modulation of genetic expression leading to resistance to virtually any antimicrobial used in clinical practice. Areas covered: This is a comprehensive review that outlines major mechanisms of resistance in the most common hospital-associated pathogens including bacteria and fungi. Expert commentary: Understanding the genetic and biochemical mechanisms of such antimicrobial adaptation is crucial to tackling the rapid spread of resistance, can expose unconventional therapeutic targets to combat multidrug resistant pathogens and lead to more accurate prediction of antimicrobial susceptibility using rapid molecular diagnostics. Clinicians making treatment decisions based on the molecular basis of resistance may design therapeutic strategies that include de-escalation of broad spectrum antimicrobial usage, more focused therapies or combination therapies. These strategies are likely to improve patient outcomes and decrease the risk of resistance in hospital settings.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1080/14787210.2018.1456919
dc.identifier.issn1744-8336
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2929
dc.language.isoeng
dc.publisherTaylor and Francisspa
dc.publisher.journalExpert Review of Anti-infective Therapyspa
dc.relation.ispartofseriesExpert Review of Anti-infective Therapy, 1744-8336, Vol 16, Num 4, 2018, pag 269-287spa
dc.relation.urihttps://www.tandfonline.com/doi/abs/10.1080/14787210.2018.1456919?journalCode=ierz20
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.armarcFarmacorresistencia microbianaspa
dc.subject.armarcInfección hospitalariaspa
dc.subject.armarcEnfermedad iatrogénicaspa
dc.subject.keywordsAntibiotic resistancespa
dc.subject.keywordsAntimicrobial resistancespa
dc.subject.keywordsNosocomial pathogensspa
dc.subject.keywordsHospital-acquired infectionsspa
dc.subject.keywordsHospital-associated pathogensspa
dc.subject.keywordsMechanisms of resistancespa
dc.titleMechanisms of antimicrobial resistance among hospital-associated pathogensspa
dc.title.translatedMechanisms of antimicrobial resistance among hospital-associated pathogensspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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